Global, regional, and national childhood cancer burden, 1990–2019: An analysis based on the Global Burden of Disease Study 2019

Ying Wu; Yujiao Deng; Bajin Wei; Dong Xiang; Jingjing Hu; Peng Zhao; Shuai Lin; Yi Zheng; Jia Yao; Zhen Zhai; Shuqian Wang; Weiyang Lou; Si Yang; Dai Zhang; Jun Lyu; Zhijun Dai

Journal of Advanced Research (Sep 2022)

Global, regional, and national childhood cancer burden, 1990–2019: An analysis based on the Global Burden of Disease Study 2019

Ying Wu,
Yujiao Deng,
Bajin Wei,
Dong Xiang,
Jingjing Hu,
Peng Zhao,
Shuai Lin,
Yi Zheng,
Jia Yao,
Zhen Zhai,
Shuqian Wang,
Weiyang Lou,
Si Yang,
Dai Zhang,
Jun Lyu,
Zhijun Dai

Affiliations

Ying Wu: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Yujiao Deng: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Bajin Wei: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Dong Xiang: Celilo Cancer Center, Oregon Health Science Center affiliated Mid-Columbia medical center, The Dalles, OR, USA
Jingjing Hu: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Peng Zhao: Department of Medical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Shuai Lin: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Yi Zheng: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Jia Yao: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Zhen Zhai: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Shuqian Wang: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Weiyang Lou: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Si Yang: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Dai Zhang: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Jun Lyu: Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China; Corresponding authors at: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (Zhijun Dai).
Zhijun Dai: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China; Corresponding authors at: Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (Zhijun Dai).

Journal volume & issue: Vol. 40
pp. 233 – 247

Abstract

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Introduction: Cancer is the leading cause of death among children. Objectives: We report on the latest estimates of the burden of cancer among children at the global, regional, and national levels from 1990 to 2019. Methods: Based on the Global Burden of Disease Study 2019, children’s cancer data were analyzed by sex, age, year, and location. Age-standardized rates were used to compare the burdens among regions and nations. Joinpoint analysis was applied to assess the temporal trend of the global childhood cancer burden. Results: In 2019, 291,319 (95% uncertainty interval [UI], 254,239 to 331,993) new cases and 98,834 (86,124 to 113,581) deaths from childhood cancer were documented globally. Further, 8,302,464 (7,230,447 to 9,555,118) DALYs and 1,806,630 (1,567,808 to 2,089,668) prevalent cases were recorded in the same year. Age-standardized incidence and prevalence rates of childhood cancer were greatest in higher SDI settings and increased most significantly in Australasia and Southern Latin America over the last 30 years. However, although age-standardized death and DALY rates of childhood cancer have remarkably decreased in all regions since 1990, countries with a lower SDI showed the highest rates in 2019, particularly in countries in Eastern Sub-Saharan Africa. Among all cancers, leukemia has shown the largest decrease in burden since 1990. Despite this, leukemia was still the most common cancer and the leading cause of death among children in 2019, followed by brain and central nervous system cancer. Conclusions: On a global scale, the childhood cancer burden has significantly fallen over the last 30 years, but is still higher in lower SDI countries. Effective interventions and collaborations among nations should be facilitated to improve healthcare among children with cancer in countries with lower SDI.

Published in Journal of Advanced Research

ISSN: 2090-1232 (Print); 2090-1224 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Science (General)
Website: http://www.journals.elsevier.com/journal-of-advanced-research/

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