EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE

D. N. Bibikov; O. A. Volokh; A. V. Komissarov; Yu. I. Samokhvalova; N. G. Avdeeva; A. K. Nikiforov

Разработка и регистрация лекарственных средств (Jan 2019)

EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE

D. N. Bibikov,
O. A. Volokh,
A. V. Komissarov,
Yu. I. Samokhvalova,
N. G. Avdeeva,
A. K. Nikiforov

Affiliations

D. N. Bibikov: Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
O. A. Volokh: Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
A. V. Komissarov: Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
Yu. I. Samokhvalova: Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
N. G. Avdeeva: Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
A. K. Nikiforov: Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare; Federal State Funded Educational Institution of Higher Postgraduate Education «N.I. Vavilov Saratov State Agrarian University», Ministry of Agriculture of the Russian Federation

Journal volume & issue: Vol. 0, no. 2
pp. 130 – 133

Abstract

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The possibility of applying sedimentation, centrifuge, and filtration techniques for concentration of F. tularensis 15 NIIEG suspensions obtained after submerged cultivation has been evaluated. It is established that realization of tangential ultrafiltration as part of technological process of live tularemia vaccine production is of distinct advantage. Characteristics of Francisella tularensis 15 NIIEG concentrate stored under different temperature/time-dependent conditions have also been studies. It is demonstrated that it is practical to preserve them at 4 °C within ≤6 days.

Published in Разработка и регистрация лекарственных средств

ISSN: 2305-2066 (Print); 2658-5049 (Online)
Publisher: LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
Country of publisher: Russian Federation
LCC subjects: Social Sciences: Industries. Land use. Labor: Special industries and trades: Pharmaceutical industry
Website: https://www.pharmjournal.ru/

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