Nature Communications (May 2020)
TFEB regulates murine liver cell fate during development and regeneration
- Nunzia Pastore,
- Tuong Huynh,
- Niculin J. Herz,
- Alessia Calcagni’,
- Tiemo J. Klisch,
- Lorenzo Brunetti,
- Kangho Ho Kim,
- Marco De Giorgi,
- Ayrea Hurley,
- Annamaria Carissimo,
- Margherita Mutarelli,
- Niya Aleksieva,
- Luca D’Orsi,
- William R. Lagor,
- David D. Moore,
- Carmine Settembre,
- Milton J. Finegold,
- Stuart J. Forbes,
- Andrea Ballabio
Affiliations
- Nunzia Pastore
- Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital
- Tuong Huynh
- Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital
- Niculin J. Herz
- Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital
- Alessia Calcagni’
- Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital
- Tiemo J. Klisch
- Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital
- Lorenzo Brunetti
- Stem Cells and Regenerative Medicine Center, Baylor College of Medicine
- Kangho Ho Kim
- Department of Molecular and Cell Biology, Baylor College of Medicine
- Marco De Giorgi
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Ayrea Hurley
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Annamaria Carissimo
- Telethon Institute of Genetics and Medicine (TIGEM)
- Margherita Mutarelli
- Telethon Institute of Genetics and Medicine (TIGEM)
- Niya Aleksieva
- MRC Centre for Regenerative Medicine, University of Edinburgh
- Luca D’Orsi
- Telethon Institute of Genetics and Medicine (TIGEM)
- William R. Lagor
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- David D. Moore
- Department of Molecular and Cell Biology, Baylor College of Medicine
- Carmine Settembre
- Telethon Institute of Genetics and Medicine (TIGEM)
- Milton J. Finegold
- Department of Pathology, Baylor College of Medicine
- Stuart J. Forbes
- MRC Centre for Regenerative Medicine, University of Edinburgh
- Andrea Ballabio
- Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital
- DOI
- https://doi.org/10.1038/s41467-020-16300-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon injury.
