Prognostic value of hematological indexes in endometrioid type endometrial cancer

Abstract

Endometrial cancer remains a significant health concern, particularly in developed nations where its prevalence is increasing. Reliable prognostic markers are paramount to enhance disease management and patient outcomes. This study explores the prognostic capabilities of various hematological indices, including the eosinophil-lymphocyte ratio (ELR) and the prognostic nutritional index (PNI), in relation to endometrioid type endometrial cancer (ETEC) staging and grading. We retrospectively analyzed data from ETEC patients, categorizing them by tumor grade and stage, and evaluating their hematological indices from preoperative blood samples. Our results indicated that higher ELR and lower PNI levels correlate with more advanced tumor grades and stages. Additionally, the platelet-lymphocyte ratio (PLR) was found to be the most significant marker for staging, with PLT, SII, SIRI, ELR, and PNI also showing significant differences across stages. These findings suggest that hematological indices such as ELR and PNI could be instrumental in predicting tumor grade and stage, offering valuable insights for clinical practice. Future research should focus on prospective studies to confirm these findings and consider the integration of these markers into standard diagnostic protocols. [Med-Science 2024; 13(3.000): 727-30]

Keywords

• hematological indices
• eosinophil-lymphocyte ratio
• prognostic nutritional index
• platelet-lymphocyte ratio
• endometrial cancer
• tumor grade
• tumor stage
• prognostic markers