Nature Communications (Sep 2018)

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

  • Hiroyuki Yoshitomi,
  • Shio Kobayashi,
  • Aya Miyagawa-Hayashino,
  • Akinori Okahata,
  • Kohei Doi,
  • Kohei Nishitani,
  • Koichi Murata,
  • Hiromu Ito,
  • Tatsuaki Tsuruyama,
  • Hironori Haga,
  • Shuichi Matsuda,
  • Junya Toguchida

DOI
https://doi.org/10.1038/s41467-018-06187-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in patients with rheumatoid arthritis.