Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators

Xueyang Dong; Ben G. H. Guthrie; Margaret Alexander; Cecilia Noecker; Lorenzo Ramirez; Nathaniel R. Glasser; Peter J. Turnbaugh; Emily P. Balskus

doi:10.1038/s41467-022-33576-3

Nature Communications (Dec 2022)

Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators

Xueyang Dong,
Ben G. H. Guthrie,
Margaret Alexander,
Cecilia Noecker,
Lorenzo Ramirez,
Nathaniel R. Glasser,
Peter J. Turnbaugh,
Emily P. Balskus

Affiliations

Xueyang Dong: Department of Chemistry and Chemical Biology, Harvard University
Ben G. H. Guthrie: Department of Microbiology & Immunology, University of California San Francisco
Margaret Alexander: Department of Microbiology & Immunology, University of California San Francisco
Cecilia Noecker: Department of Microbiology & Immunology, University of California San Francisco
Lorenzo Ramirez: Department of Microbiology & Immunology, University of California San Francisco
Nathaniel R. Glasser: Department of Chemistry and Chemical Biology, Harvard University
Peter J. Turnbaugh: Department of Microbiology & Immunology, University of California San Francisco
Emily P. Balskus: Department of Chemistry and Chemical Biology, Harvard University

DOI: https://doi.org/10.1038/s41467-022-33576-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Eggerthella lenta is a prominent human gut bacterium implicated in several physiological processes, but its study has remained limited. Here, by developing a genetic toolbox for E. lenta, the authors provide insights into how the bacterium regulates drug and dietary compound metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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