Hypertension in Pregnancy (Jul 2021)

Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study

  • Petar Cabunac,
  • Nataša Karadžov Orlić,
  • Daniela Ardalić,
  • Barbara Damnjanović Pažin,
  • Srđan Stanimirović,
  • Gorica Banjac,
  • Aleksandra Stefanović,
  • Vesna Spasojević- Kalimanovska,
  • Amira Egić,
  • Nina Rajović,
  • Nataša Milić,
  • Željko Miković

DOI
https://doi.org/10.1080/10641955.2021.1921791
Journal volume & issue
Vol. 40, no. 3
pp. 171 – 179

Abstract

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OBJECTIVE: This study aimed to assess the accuracy of The Fetal Medicine Foundation (FMF) screening algorithm for the prediction of preeclampsia. METHODS: Out of 138 women with high-risk pregnancies prospectively followed, 30 developed preeclampsia. The clinical examination and biochemical measurements were performed at first, second, early and late third trimester. RESULTS: A lower PAPP-A levels were found in the first trimester, while sFlt/PlGF was increased in the second and early third trimester in preeclampsia (p>0.05). FMF algorithm presented higher specificity (>70%), but had a drawback of lower sensitivity (35–77%). CONCLUSION: FMF algorithm had modest performance in the prediction of preeclampsia for high-risk pregnancies.

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