ADP binding by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals

Ines Martin-Martin; Andrew Paige; Paola Carolina Valenzuela Leon; Apostolos G. Gittis; Olivia Kern; Brian Bonilla; Andrezza Campos Chagas; Sundar Ganesan; Leticia Barion Smith; David N. Garboczi; Eric Calvo

doi:10.1038/s41467-020-16665-z

Nature Communications (Jun 2020)

ADP binding by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals

Ines Martin-Martin,
Andrew Paige,
Paola Carolina Valenzuela Leon,
Apostolos G. Gittis,
Olivia Kern,
Brian Bonilla,
Andrezza Campos Chagas,
Sundar Ganesan,
Leticia Barion Smith,
David N. Garboczi,
Eric Calvo

Affiliations

Ines Martin-Martin: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Andrew Paige: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Paola Carolina Valenzuela Leon: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Apostolos G. Gittis: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Olivia Kern: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Brian Bonilla: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Andrezza Campos Chagas: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Sundar Ganesan: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Leticia Barion Smith: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
David N. Garboczi: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Eric Calvo: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-020-16665-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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D7 proteins are highly abundant in the salivary glands of several blood feeding insects. Here, the authors study the ligand binding specificity and physiological roles of the mosquito D7 proteins CxD7L1 and CxD7L2, showing that CxD7L1 acquired ADP-binding properties to enhance blood feeding in mammals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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