Fungal dysbiosis facilitates inflammatory bowel disease by enhancing CD4+ T cell glutaminolysis

Minhao Yu; Hui Ding; Hui Ding; Shuai Gong; Shuai Gong; Yang Luo; Haiping Lin; Yifei Mu; Hao Li; Xiaobo Li; Xiaobo Li; Ming Zhong

doi:10.3389/fcimb.2023.1140757

Frontiers in Cellular and Infection Microbiology (Apr 2023)

Fungal dysbiosis facilitates inflammatory bowel disease by enhancing CD4+ T cell glutaminolysis

Minhao Yu,
Hui Ding,
Hui Ding,
Shuai Gong,
Shuai Gong,
Yang Luo,
Haiping Lin,
Yifei Mu,
Hao Li,
Xiaobo Li,
Xiaobo Li,
Ming Zhong

Affiliations

Minhao Yu: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Hui Ding: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Hui Ding: Shanghai Institute of Digestive Disease, National Health Commission (NHC) Key Laboratory of Digestive Diseases, Shanghai, China
Shuai Gong: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shuai Gong: Shanghai Institute of Digestive Disease, National Health Commission (NHC) Key Laboratory of Digestive Diseases, Shanghai, China
Yang Luo: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Haiping Lin: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Yifei Mu: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Hao Li: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Xiaobo Li: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Xiaobo Li: Shanghai Institute of Digestive Disease, National Health Commission (NHC) Key Laboratory of Digestive Diseases, Shanghai, China
Ming Zhong: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

DOI: https://doi.org/10.3389/fcimb.2023.1140757
Journal volume & issue: Vol. 13

Abstract

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The fungal microbiota is an important component of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation. However, how fungi regulate inflammatory bowel disease (IBD) is poorly understood. This study found that intestinal fungi regulate immune responses in IBD. Antibiotic-mediated depletion of fungi facilitated the development of IBD. Fungi greatly enhanced oxidative phosphorylation (OXPHOS) by enhancing glutaminolysis. Mechanistically, we found that fungi could activate the dectin-1-Syk- NF-κB signaling pathway to promote the expression of key enzymes and transporters involved in glutaminolysis. In summary, our findings reveal that fungal interactions in the human gut could be a promising therapeutic target for IBD.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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