The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia

Shujie Chen; Jing Zhong; Qunyan Zhou; Xiaofeng Lu; Liangjing Wang; Jianmin Si

doi:10.1155/2011/403956

Gastroenterology Research and Practice (Jan 2011)

The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia

Shujie Chen,
Jing Zhong,
Qunyan Zhou,
Xiaofeng Lu,
Liangjing Wang,
Jianmin Si

Affiliations

Shujie Chen: Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China
Jing Zhong: Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
Qunyan Zhou: Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China
Xiaofeng Lu: Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China
Liangjing Wang: Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
Jianmin Si: Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China

DOI: https://doi.org/10.1155/2011/403956
Journal volume & issue: Vol. 2011

Abstract

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The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P<0.05), while the number of glands dramatically decreased (P<0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P<0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P<0.05). Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats.

Published in Gastroenterology Research and Practice

ISSN: 1687-6121 (Print); 1687-630X (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://onlinelibrary.wiley.com/journal/6480

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