Autoimmune Diseases (Jan 2014)

A Metabolomic Perspective on Coeliac Disease

  • Antonio Calabrò,
  • Ewa Gralka,
  • Claudio Luchinat,
  • Edoardo Saccenti,
  • Leonardo Tenori

DOI
https://doi.org/10.1155/2014/756138
Journal volume & issue
Vol. 2014

Abstract

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Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. A metabolomics investigation of coeliac disease (CD) revealed that a metabolic fingerprint for CD can be defined, which accounts for three different but complementary components: malabsorption, energy metabolism, and alterations in gut microflora and/or intestinal permeability. In this review, we will discuss the major advancements in metabolomics of CD, in particular with respect to the role of gut microbiome and energy metabolism.