Serum Levels of Pro-Brain Natriuretic Peptide and the Diagnosis and Prognosis of Cardiac Syncope

Abstract

Introduction: Recently, various serum markers have been used for the diagnosis and prognosis of acute heart diseases in emergency departments. Thus, the present study was designed and conducted to determine such a role.Methods: This is an Analytical Cross-Sectional study conducted on the patients with syncope complaints. The patients were entered the study based on the inclusion and exclusion criteria and were subjected to initial evaluations including history, physical examination, ECG, blood sugar measurement, and, if necessary, brain CT scan, Doppler echocardiography, and CTA.Results: A hundred people complaining of syncope were included in this study. The results showed that 19% and 81% of the subjects were suffering from cardiac and non-cardiac syncope, respectively. The average Pro BNP of the studied individuals was 196.06 ± 128.45 pg/ml. according to the results, age and length of hospitalization had a positive and significant relationship with the average Pro BNP (P value<0.01). Furthermore, the average Pro BNP was significantly higher in the people with positive TPI, cardiac syncope, and abnormalities in ECG and Doppler findings (P value<0.01). The results of the diagnostic value of Pro BNP in identifying cardiac syncope also showed that its sensitivity and specificity were 94.73% and 56.79%, respectively.Conclusion: The results of this study showed that the increase in the Pro BNP values was associated with age, increased length of hospitalization, and ECG abnormalities. In addition, as an independent marker, Pro BNP had good acceptability in identifying cardiac syncope cases.

Keywords

• syncope
• emergency department
• bnp
• prognosis