Computed Tomography-Based Investigation on the Effects of Intravenous Bisphosphonate Administration on Tooth Growth in a Minipig Animal Model
Philipp Poxleitner,
Pit J. Voss,
David Steybe,
Lisa-Marie Seibert,
Stephan Zeiter,
Martin J. Stoddart,
Rainer Schmelzeisen,
Sven Otto
Affiliations
Philipp Poxleitner
Department of Oral and Maxillofacial Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Pit J. Voss
Department of Oral and Maxillofacial Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
David Steybe
Department of Oral and Maxillofacial Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Lisa-Marie Seibert
Department of Oral and Maxillofacial Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Stephan Zeiter
AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland
Martin J. Stoddart
AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland
Rainer Schmelzeisen
Department of Oral and Maxillofacial Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Sven Otto
Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University Munich, Lindwurmstr. 2a, 80337 Munich, Germany
Background and Objectives: The objective of this study was to evaluate the effects of bisphosphonate (BP) administration on tooth growth, using CT-data of a minipig animal model investigation. Materials and Methods: Tooth growth was evaluated in minipigs, with eight animals receiving weekly zoledronate (ZOL) and three animals serving as the control group. Tooth growth was evaluated at the right 2nd molar (M2) in the maxilla. A computed tomography-based measuring method was applied to evaluate tooth growth in the coronal-apical, buccal-oral and mesial-distal axis. Results: ZOL-administration was found to impact tooth growth in all evaluated measuring axes, with the highest effect observed in the coronal-apical axis. Conclusions: Detrimental effects of BP administration on growing teeth have been reported by a number of investigators. The results of this investigation demonstrate that intravenous ZOL affects the growth of the whole tooth within a short period of administration. With BPs being administered to a growing number of pediatric patients, further studies should be conducted to qualify and quantify the effects of BPs on developing teeth.
