The concerted roles of FANCM and Rad52 in the protection of common fragile sites

Hailong Wang; Shibo Li; Joshua Oaks; Jianping Ren; Lei Li; Xiaohua Wu

doi:10.1038/s41467-018-05066-y

Nature Communications (Jul 2018)

The concerted roles of FANCM and Rad52 in the protection of common fragile sites

Hailong Wang,
Shibo Li,
Joshua Oaks,
Jianping Ren,
Lei Li,
Xiaohua Wu

Affiliations

Hailong Wang: Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University
Shibo Li: Department of Molecular Medicine, The Scripps Research Institute
Joshua Oaks: Department of Molecular Medicine, The Scripps Research Institute
Jianping Ren: Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University
Lei Li: Department of Genetics, The University of Texas M.D. Anderson Cancer Center
Xiaohua Wu: Department of Molecular Medicine, The Scripps Research Institute

DOI: https://doi.org/10.1038/s41467-018-05066-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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