Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

V. Pragathi Masamsetti; Ronnie Ren Jie Low; Ka Sin Mak; Aisling O’Connor; Chris D. Riffkin; Noa Lamm; Laure Crabbe; Jan Karlseder; David C. S. Huang; Makoto T. Hayashi; Anthony J. Cesare

doi:10.1038/s41467-019-12255-w

Nature Communications (Sep 2019)

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

V. Pragathi Masamsetti,
Ronnie Ren Jie Low,
Ka Sin Mak,
Aisling O’Connor,
Chris D. Riffkin,
Noa Lamm,
Laure Crabbe,
Jan Karlseder,
David C. S. Huang,
Makoto T. Hayashi,
Anthony J. Cesare

Affiliations

V. Pragathi Masamsetti: Children’s Medical Research Institute, University of Sydney
Ronnie Ren Jie Low: Children’s Medical Research Institute, University of Sydney
Ka Sin Mak: Children’s Medical Research Institute, University of Sydney
Aisling O’Connor: Children’s Medical Research Institute, University of Sydney
Chris D. Riffkin: The Walter and Eliza Hall Institute of Medical Research
Noa Lamm: Children’s Medical Research Institute, University of Sydney
Laure Crabbe: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
Jan Karlseder: The Salk Institute for Biological Studies, Molecular and Cell Biology Department
David C. S. Huang: The Walter and Eliza Hall Institute of Medical Research
Makoto T. Hayashi: Department of Gene Mechanisms, Graduate School of Biostudies/The Hakubi Center for Advanced Research, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku
Anthony J. Cesare: Children’s Medical Research Institute, University of Sydney

DOI: https://doi.org/10.1038/s41467-019-12255-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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