Nature Communications (Jul 2019)
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
- Xiaopu Zhou,
- Yu Chen,
- Kin Y. Mok,
- Timothy C. Y. Kwok,
- Vincent C. T. Mok,
- Qihao Guo,
- Fanny C. Ip,
- Yuewen Chen,
- Nandita Mullapudi,
- Alzheimer’s Disease Neuroimaging Initiative,
- Paola Giusti-Rodríguez,
- Patrick F. Sullivan,
- John Hardy,
- Amy K. Y. Fu,
- Yun Li,
- Nancy Y. Ip
Affiliations
- Xiaopu Zhou
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Yu Chen
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Kin Y. Mok
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Timothy C. Y. Kwok
- Therese Pei Fong Chow Research Centre for Prevention of Dementia, Division of Geriatrics, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Vincent C. T. Mok
- Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Qihao Guo
- Department of Neurology, Huashan Hospital, Fudan University
- Fanny C. Ip
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Yuewen Chen
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Nandita Mullapudi
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Alzheimer’s Disease Neuroimaging Initiative
- Department of Genetics, University of North Carolina
- Paola Giusti-Rodríguez
- Department of Genetics, University of North Carolina
- Patrick F. Sullivan
- Department of Genetics, University of North Carolina
- John Hardy
- Department of Molecular Neuroscience, University College London Institute of Neurology
- Amy K. Y. Fu
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- Yun Li
- Department of Genetics, University of North Carolina
- Nancy Y. Ip
- Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-019-10945-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.
