eLife (Oct 2019)
Electric field causes volumetric changes in the human brain
- Miklos Argyelan,
- Leif Oltedal,
- Zhi-De Deng,
- Benjamin Wade,
- Marom Bikson,
- Andrea Joanlanne,
- Sohag Sanghani,
- Hauke Bartsch,
- Marta Cano,
- Anders M Dale,
- Udo Dannlowski,
- Annemiek Dols,
- Verena Enneking,
- Randall Espinoza,
- Ute Kessler,
- Katherine L Narr,
- Ketil J Oedegaard,
- Mardien L Oudega,
- Ronny Redlich,
- Max L Stek,
- Akihiro Takamiya,
- Louise Emsell,
- Filip Bouckaert,
- Pascal Sienaert,
- Jesus Pujol,
- Indira Tendolkar,
- Philip van Eijndhoven,
- Georgios Petrides,
- Anil K Malhotra,
- Christopher Abbott
Affiliations
- Miklos Argyelan
- ORCiD
- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, United States; Department of Psychiatry, Zucker School of Medicine, Hempstead, United States
- Leif Oltedal
- Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Mohn Medical Imaging and Visualization Centre, Bergen, Norway
- Zhi-De Deng
- Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, United States
- Benjamin Wade
- Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, United States
- Marom Bikson
- Department of Biomedical Engineering, The City College of the City University of New York, New York, United States
- Andrea Joanlanne
- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States
- Sohag Sanghani
- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States
- Hauke Bartsch
- Department of Radiology, Haukeland University Hospital, Mohn Medical Imaging and Visualization Centre, Bergen, Norway; Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, United States
- Marta Cano
- ORCiD
- Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Barcelona, Spain
- Anders M Dale
- Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, United States; Department of Radiology, University of California, San Diego, San Diego, United States; Department of Neurosciences, University of California, San Diego, San Diego, United States
- Udo Dannlowski
- Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
- Annemiek Dols
- Department of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands
- Verena Enneking
- Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
- Randall Espinoza
- Department of Neurology, University of California, Los Angeles, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States
- Ute Kessler
- Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, University of Bergen, Bergen, Norway
- Katherine L Narr
- Department of Neurology, University of California, Los Angeles, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States
- Ketil J Oedegaard
- Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, University of Bergen, Bergen, Norway
- Mardien L Oudega
- Department of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands
- Ronny Redlich
- Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
- Max L Stek
- Department of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands
- Akihiro Takamiya
- Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Center for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, Japan
- Louise Emsell
- Department of Geriatric Psychiatry, University Psychiatric Center, KU Leuven, Leuven, Belgium
- Filip Bouckaert
- Department of Geriatric Psychiatry, University Psychiatric Center, KU Leuven, Leuven, Belgium; Academic center for ECT and Neurostimulation (AcCENT), University Psychiatric Center, KU Leuven, Kortenberg, Belgium
- Pascal Sienaert
- Academic center for ECT and Neurostimulation (AcCENT), University Psychiatric Center, KU Leuven, Kortenberg, Belgium
- Jesus Pujol
- CIBERSAM, Carlos III Health Institute, Barcelona, Spain; MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain
- Indira Tendolkar
- Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands; Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, Netherlands; Faculty of Medicine and LVR Clinic for Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, Germany
- Philip van Eijndhoven
- Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands; Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, Netherlands
- Georgios Petrides
- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, United States; Department of Psychiatry, Zucker School of Medicine, Hempstead, United States
- Anil K Malhotra
- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, United States; Department of Psychiatry, Zucker School of Medicine, Hempstead, United States
- Christopher Abbott
- Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, United States
- DOI
- https://doi.org/10.7554/eLife.49115
- Journal volume & issue
-
Vol. 8
Abstract
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
Keywords
