Zhongguo shuxue zazhi (Feb 2023)

Analysis of ABO gene mRNA expression in peripheral blood of patients with acute myeloid leukemia

  • Shihang ZHOU,
  • Ni WANG,
  • Ming LIU,
  • Yaxin FAN

DOI
https://doi.org/10.13303/j.cjbt.issn.1004-549x.2023.02.005
Journal volume & issue
Vol. 36, no. 2
pp. 112 – 115

Abstract

Read online

Objective To investigate the expression characteristics of ABO gene mRNA in peripheral blood of patients with acute myeloid leukemia. Methods The RNA-seq data of acute myeloid leukemia in TCGA database and the whole blood RNA-seq data in GTEx database were downloaded. The difference of ABO gene mRNA expression between acute myeloid leukemia and GTEx whole blood samples was analyzed by R software, and the relationship between ABO gene mRNA expression and DNA methylation, immune infiltration and prognosis was analyzed. Results The expression level of ABO gene mRNA in acute myeloid leukemia(median: 1.333, P25: 3.654, P75: 0.401)was significantly lower than that in the control group(median: 3.576, P25: 3.747, P75: 3.470)(P0.05). Conclusion The mRNA expression of ABO gene in peripheral blood of patients with acute myeloid leukemia is decreased, which is associated with DNA methylation of the first intron of ABO gene and immune infiltration, but not with the prognosis.

Keywords