Haseki Tıp Bülteni (Sep 2014)

A Case of Atypical (Cellular) Congenital Mesoblastic Nephroma Presenting with High Serum Levels of Neuron Specific Enolase in Neonatal Period

  • Nihan Hilal Hoşağası,
  • Dilek Dilli,
  • İsmet Faruk Özgüner,
  • Gürses Şahin,
  • Esin Cengiz Boduroğlu,
  • Banu Aydın,
  • Nuran Üstün,
  • Aysegül Zenciroğlu,
  • Nurullah Okumuş,
  • Burak Özkan

DOI
https://doi.org/10.4274/haseki.1577
Journal volume & issue
Vol. 52, no. 3
pp. 223 – 226

Abstract

Read online

The most common causes of abdominal mass are neuroblastoma, germ cell tumors, hepatoblastoma and congenital mesoblastic nephroma. Congenital mesoblastic nephroma (CMN) accounts for more than 90% of all renal tumors seen in the first three months of life. Total nephrectomy is curative. Neuron-specific enolase is a glycolytic enzyme that is localized primarily to the neuronal cytoplasm. Its sensitivity is especially high for neuroblastoma and small cell lung cancer. In this paper, we report a newborn with abdominal mass that was firstly considered as neuroblastoma due to calcifications observed on ultrasonography and high levels of serum neuron-specific enolase. After histopathological evaluation of the lesion, the patient was diagnosed as having atypical (cellular) congenital mesoblastic nephroma. (The Me­di­cal Bul­le­tin of Ha­se­ki 2014; 52: 223-6)

Keywords