Nature Communications (Mar 2023)
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
- William J. Young,
- Jeffrey Haessler,
- Jan-Walter Benjamins,
- Linda Repetto,
- Jie Yao,
- Aaron Isaacs,
- Andrew R. Harper,
- Julia Ramirez,
- Sophie Garnier,
- Stefan van Duijvenboden,
- Antoine R. Baldassari,
- Maria Pina Concas,
- ThuyVy Duong,
- Luisa Foco,
- Jonas L. Isaksen,
- Hao Mei,
- Raymond Noordam,
- Casia Nursyifa,
- Anne Richmond,
- Meddly L. Santolalla,
- Colleen M. Sitlani,
- Negin Soroush,
- Sébastien Thériault,
- Stella Trompet,
- Stefanie Aeschbacher,
- Fariba Ahmadizar,
- Alvaro Alonso,
- Jennifer A. Brody,
- Archie Campbell,
- Adolfo Correa,
- Dawood Darbar,
- Antonio De Luca,
- Jean-François Deleuze,
- Christina Ellervik,
- Christian Fuchsberger,
- Anuj Goel,
- Christopher Grace,
- Xiuqing Guo,
- Torben Hansen,
- Susan R. Heckbert,
- Rebecca D. Jackson,
- Jan A. Kors,
- Maria Fernanda Lima-Costa,
- Allan Linneberg,
- Peter W. Macfarlane,
- Alanna C. Morrison,
- Pau Navarro,
- David J. Porteous,
- Peter P. Pramstaller,
- Alexander P. Reiner,
- Lorenz Risch,
- Ulrich Schotten,
- Xia Shen,
- Gianfranco Sinagra,
- Elsayed Z. Soliman,
- Monika Stoll,
- Eduardo Tarazona-Santos,
- Andrew Tinker,
- Katerina Trajanoska,
- Eric Villard,
- Helen R. Warren,
- Eric A. Whitsel,
- Kerri L. Wiggins,
- Dan E. Arking,
- Christy L. Avery,
- David Conen,
- Giorgia Girotto,
- Niels Grarup,
- Caroline Hayward,
- J.Wouter Jukema,
- Dennis O. Mook-Kanamori,
- Morten Salling Olesen,
- Sandosh Padmanabhan,
- Bruce M. Psaty,
- Cristian Pattaro,
- Antonio Luiz P. Ribeiro,
- Jerome I. Rotter,
- Bruno H. Stricker,
- Pim van der Harst,
- Cornelia M. van Duijn,
- Niek Verweij,
- James G. Wilson,
- Michele Orini,
- Philippe Charron,
- Hugh Watkins,
- Charles Kooperberg,
- Henry J. Lin,
- James F. Wilson,
- Jørgen K. Kanters,
- Nona Sotoodehnia,
- Borbala Mifsud,
- Pier D. Lambiase,
- Larisa G. Tereshchenko,
- Patricia B. Munroe
Affiliations
- William J. Young
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Jeffrey Haessler
- Public Health Sciences Division, Fred Hutchinson Cancer Center
- Jan-Walter Benjamins
- University of Groningen, University Medical Center Groningen, Department of Cardiology
- Linda Repetto
- Centre for Global Health Research, Usher Institute, University of Edinburgh
- Jie Yao
- Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center
- Aaron Isaacs
- Dept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University
- Andrew R. Harper
- Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital
- Julia Ramirez
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Sophie Garnier
- Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease
- Stefan van Duijvenboden
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Antoine R. Baldassari
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Maria Pina Concas
- Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”
- ThuyVy Duong
- McKusick‐Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine
- Luisa Foco
- Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck)
- Jonas L. Isaksen
- Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen
- Hao Mei
- Department of Data Science, University of Mississippi Medical Center
- Raymond Noordam
- Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center
- Casia Nursyifa
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Anne Richmond
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
- Meddly L. Santolalla
- Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Colleen M. Sitlani
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Negin Soroush
- Department of Epidemiology, Erasmus Medical Center
- Sébastien Thériault
- Population Health Research Institute, McMaster University
- Stella Trompet
- Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center
- Stefanie Aeschbacher
- Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel
- Fariba Ahmadizar
- Department of Epidemiology, Erasmus Medical Center
- Alvaro Alonso
- Department of Epidemiology, Rollins School of Public Health, Emory University
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Archie Campbell
- Usher Institute, University of Edinburgh
- Adolfo Correa
- Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center
- Dawood Darbar
- Department of Medicine, University of Illinois at Chicago
- Antonio De Luca
- Cardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste
- Jean-François Deleuze
- Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH)
- Christina Ellervik
- Department of Data and Data Support, Region Zealand
- Christian Fuchsberger
- Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck)
- Anuj Goel
- Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital
- Christopher Grace
- Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital
- Xiuqing Guo
- Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center
- Torben Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Susan R. Heckbert
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Rebecca D. Jackson
- Center for Clinical and Translational Science, Ohio State Medical Center
- Jan A. Kors
- Department of Medical Informatics, Erasmus University Medical Center
- Maria Fernanda Lima-Costa
- Instituto René Rachou, fundação Oswaldo Cruz
- Allan Linneberg
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- Peter W. Macfarlane
- Institute of Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Pau Navarro
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
- David J. Porteous
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Peter P. Pramstaller
- Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck)
- Alexander P. Reiner
- Department of Epidemiology, University of Washington
- Lorenz Risch
- Labormedizinisches zentrum Dr. Risch
- Ulrich Schotten
- Dept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University
- Xia Shen
- Centre for Global Health Research, Usher Institute, University of Edinburgh
- Gianfranco Sinagra
- Cardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste
- Elsayed Z. Soliman
- Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine
- Monika Stoll
- Maastricht Center for Systems Biology (MaCSBio), Maastricht University
- Eduardo Tarazona-Santos
- Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Andrew Tinker
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Katerina Trajanoska
- Department of Internal Medicine, Erasmus Medical Center
- Eric Villard
- Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease
- Helen R. Warren
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Eric A. Whitsel
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Kerri L. Wiggins
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Dan E. Arking
- McKusick‐Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine
- Christy L. Avery
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- David Conen
- Population Health Research Institute, McMaster University
- Giorgia Girotto
- Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”
- Niels Grarup
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Caroline Hayward
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- J.Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
- Morten Salling Olesen
- Department of Biomedical Sciences, University of Copenhagen
- Sandosh Padmanabhan
- Institute of Cardiovascular and Medical Sciences, University of Glasgow
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Cristian Pattaro
- Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck)
- Antonio Luiz P. Ribeiro
- Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center
- Bruno H. Stricker
- Department of Epidemiology, Erasmus Medical Center
- Pim van der Harst
- University of Groningen, University Medical Center Groningen, Department of Cardiology
- Cornelia M. van Duijn
- Nuffield Department of Population Health, University of Oxford
- Niek Verweij
- University of Groningen, University Medical Center Groningen, Department of Cardiology
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Michele Orini
- Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS trust
- Philippe Charron
- Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease
- Hugh Watkins
- Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital
- Charles Kooperberg
- Public Health Sciences Division, Fred Hutchinson Cancer Center
- Henry J. Lin
- Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center
- James F. Wilson
- Centre for Global Health Research, Usher Institute, University of Edinburgh
- Jørgen K. Kanters
- Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington
- Borbala Mifsud
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Pier D. Lambiase
- Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS trust
- Larisa G. Tereshchenko
- Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic
- Patricia B. Munroe
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- DOI
- https://doi.org/10.1038/s41467-023-36997-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.
