Nature Communications (Jan 2021)

Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers

  • Alexander A. Shcherbakov,
  • Grant Hisao,
  • Venkata S. Mandala,
  • Nathan E. Thomas,
  • Mohammad Soltani,
  • E. A. Salter,
  • James H. Davis,
  • Katherine A. Henzler-Wildman,
  • Mei Hong

DOI
https://doi.org/10.1038/s41467-020-20468-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The small proton-coupled transporter EmrE confers multidrug resistance in bacteria. The structure of drug-bound EmrE in phospholipid bilayers is now determined using solid-state NMR. The structure provides detailed insights into the molecular mechanism of substrate recognition by this transporter.