Respiratory Research (Oct 2022)

Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis

  • Tian Jiang,
  • Weiping Hu,
  • Shaoyuan Zhang,
  • Changhao Ren,
  • Siyun Lin,
  • Zhenyu Zhou,
  • Hao Wu,
  • Jun Yin,
  • Lijie Tan

DOI
https://doi.org/10.1186/s12931-022-02193-5
Journal volume & issue
Vol. 23, no. 1
pp. 1 – 15

Abstract

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Highlights It is the first time to prove the confirm the endothelial glycocalyx impairment in COPD. FGF10 attenuates the development of emphysema and the shedding of glycocalyx induced by CSE in vivo. FGF10 alleviates smoke-induced endothelial apoptosis and glycocalyx repair through FGFR1/ERK/SOX9/HS6ST1 signaling.

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