Maturation of Arousals during Day and Night in Preterm Infants
Aurore Guyon,
Francoise Ravet,
Alex Champavert,
Marine Thieux,
Hugues Patural,
Sabine Plancoulaine,
Patricia Franco
Affiliations
Aurore Guyon
Unité de Sommeil, Service D’épilepsie, Sommeil et Explorations Fonctionnelles Neurologiques Pédiatriques—INSERM U1028—Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 59 bd Pinel Bron, 69500 Lyon, France
Francoise Ravet
Unité de Sommeil Pédiatrique—Département Universitaire de Pédiatrie du CHU Liège—Site CHR, 1 bd du XIIème de Ligne, 4000 Liège, Belgium
Alex Champavert
Unité de Sommeil, Service D’épilepsie, Sommeil et Explorations Fonctionnelles Neurologiques Pédiatriques—INSERM U1028—Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 59 bd Pinel Bron, 69500 Lyon, France
Marine Thieux
Unité de Sommeil, Service D’épilepsie, Sommeil et Explorations Fonctionnelles Neurologiques Pédiatriques—INSERM U1028—Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 59 bd Pinel Bron, 69500 Lyon, France
Hugues Patural
Neonatal and Pediatric Intensive Care Department, Inserm, U1059, University Hospital of Saint Etienne, 42270 Saint Etienne, France
Sabine Plancoulaine
Centre of Research in Epidemiology and StatisticS (CRESS), Inserm, INRAE, Université de Paris Cité, F-75004 Paris, France
Patricia Franco
Unité de Sommeil, Service D’épilepsie, Sommeil et Explorations Fonctionnelles Neurologiques Pédiatriques—INSERM U1028—Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 59 bd Pinel Bron, 69500 Lyon, France
The objective of this study was to compare the maturation of spontaneous arousals during day and night sleep in preterm and term infants. From the Autonomic Baby Evaluation study, the sleep and arousal characteristics of 12 preterm (35.1 ± 2.1 weeks’ gestational age, GA) and 21 term (39.8 ± 0.8 weeks GA) newborns were compared between diurnal and nocturnal sleep periods at birth (M0) and 6 months (M6) of age. Models were adjusted for time (night/day), maturation (M0/M6), prematurity (yes/no). We found that preterm infants had less active sleep (AS)% than term infants with maturation during both day and night sleep, which may reflect accelerated brain maturation secondary to stress or environmental exposure after birth. Moreover, there was a difference in arousal maturation during day and night sleep in the preterm infants, as shown previously for term infants, which suggests the emergence of a circadian rhythm during the earliest postnatal period. We also showed that compared to term infants, these moderate preterm infants had fewer total arousals and, more specifically, fewer arousals in AS during day and night sleep, exposing them to a higher risk of sudden infant death syndrome.
