Circular RNA hsa_circ_0051040 Promotes Hepatocellular Carcinoma Progression by Sponging miR-569 and Regulating ITGAV Expression

Linling Ju; Min Yao; Rujian Lu; Yali Cao; Huixuan Wang; Liuxia Yuan; Feng Xiao; Jianguo Shao; Weihua Cai; Lin Chen; Zhaolian Bian

doi:10.3390/cells11223571

Cells (Nov 2022)

Circular RNA hsa_circ_0051040 Promotes Hepatocellular Carcinoma Progression by Sponging miR-569 and Regulating ITGAV Expression

Linling Ju,
Min Yao,
Rujian Lu,
Yali Cao,
Huixuan Wang,
Liuxia Yuan,
Feng Xiao,
Jianguo Shao,
Weihua Cai,
Lin Chen,
Zhaolian Bian

Affiliations

Linling Ju: Medical School of Nantong University, Nantong University, Nantong 226001, China
Min Yao: Medical School of Nantong University, Nantong University, Nantong 226001, China
Rujian Lu: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Yali Cao: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Huixuan Wang: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Liuxia Yuan: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Feng Xiao: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Jianguo Shao: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Weihua Cai: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Lin Chen: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China
Zhaolian Bian: Nantong Institute of Liver Disease, Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People’s Hospital, Nantong University, Nantong 226006, China

DOI: https://doi.org/10.3390/cells11223571
Journal volume & issue: Vol. 11, no. 22
p. 3571

Abstract

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Accumulating evidence has demonstrated the roles of circular RNAs (circRNAs) in hepatocellular carcinoma (HCC); however, their roles in HCC need to be further studied. Through high-throughput human circRNA microarray analysis of HCC and adjacent normal tissues, we identified hsa_circ_0051040 as a novel candidate circRNA for the diagnosis and treatment of HCC. In this study, we found that hsa_circ_0051040 was overexpressed in HCC tissues and cell lines and that its expression was correlated with poor prognosis. Knockdown of hsa_circ_0051040 inhibited the migration, invasion, and proliferation of HCC cells in vitro and in vivo, whereas overexpression of hsa_circ_0051040 had the opposite effects. Moreover, our data demonstrated that hsa_circ_0051040 acted as a sponge for miR-569 to regulate ITGAV expression and induce EMT progression. Our findings indicated that hsa_circ_0051040 promotes HCC development and progression by sponging miR-569 to increase ITGAV expression. Thus, hsa_circ_0051040 is a good candidate as a therapeutic target.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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