Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy

Abstract

Introduction Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow‐up periods are growing longer, the rate of unusual visceral metastases may increase. Case presentation A 68‐year‐old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow‐up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow‐up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma. Conclusion We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long‐term follow‐up.

Keywords

• bladder metastasis
• esophageal metastasis
• renal cell cancer