Influence of wortmannin of aggregation ability of neutrophylic granulocytes under type 1 diabetes mellitus

Abstract

The determination wortmanin influence on aggregation ability of neutro­phylic granulocytes induced by specific lectins such as WGA, SNA and MAA was conducted. Distinct functional changes of the leucocytes under type 1 diabetes mellitus contingently by quantitative increasing of plasmatic membrane sialic containing glycoprotein receptors which contain in their structure NeuNAc(α2→6)DGal/DgalNAc carbohydrate, but not NeuNAc(α2→3)DGal/DgalNAc carbohydrate were revealed. Enhanced ability of neutrophylic granulocytes aggregation under influence of specific lectins at type 1 diabetes mellitus and weak answer of wortmanin inhibition may used as test system for determination of dearrangements in functional changes of the leukocytes under type 1 diabetes mellitus.

Keywords

• neutrohylic granulocytes
• sialic containing glycoprotein
• lectin induced aggregation
• type 1 diabetes mellitus