Nature Communications (Mar 2023)
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity
- Kaitlin A. Read,
- Devin M. Jones,
- Srijana Pokhrel,
- Emily D. S. Hales,
- Aditi Varkey,
- Jasmine A. Tuazon,
- Caprice D. Eisele,
- Omar Abdouni,
- Abbey Saadey,
- Melissa R. Leonard,
- Robert T. Warren,
- Michael D. Powell,
- Jeremy M. Boss,
- Emily A. Hemann,
- Jacob S. Yount,
- Gang Xin,
- Hazem E. Ghoneim,
- Chan-Wang J. Lio,
- Aharon G. Freud,
- Patrick L. Collins,
- Kenneth J. Oestreich
Affiliations
- Kaitlin A. Read
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Devin M. Jones
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Srijana Pokhrel
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Emily D. S. Hales
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Aditi Varkey
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Jasmine A. Tuazon
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Caprice D. Eisele
- Biomedical Sciences Graduate Program
- Omar Abdouni
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Abbey Saadey
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Melissa R. Leonard
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Robert T. Warren
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Michael D. Powell
- Department of Microbiology and Immunology, Emory University School of Medicine
- Jeremy M. Boss
- Department of Microbiology and Immunology, Emory University School of Medicine
- Emily A. Hemann
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Jacob S. Yount
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Gang Xin
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Hazem E. Ghoneim
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Chan-Wang J. Lio
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Aharon G. Freud
- Department of Pathology, The Ohio State University College of Medicine and Wexner Medical Center
- Patrick L. Collins
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- Kenneth J. Oestreich
- Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center
- DOI
- https://doi.org/10.1038/s41467-023-37420-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages.
