Dynamic control of decision and movement speed in the human basal ganglia

Damian M. Herz; Manuel Bange; Gabriel Gonzalez-Escamilla; Miriam Auer; Keyoumars Ashkan; Petra Fischer; Huiling Tan; Rafal Bogacz; Muthuraman Muthuraman; Sergiu Groppa; Peter Brown

doi:10.1038/s41467-022-35121-8

Nature Communications (Dec 2022)

Dynamic control of decision and movement speed in the human basal ganglia

Damian M. Herz,
Manuel Bange,
Gabriel Gonzalez-Escamilla,
Miriam Auer,
Keyoumars Ashkan,
Petra Fischer,
Huiling Tan,
Rafal Bogacz,
Muthuraman Muthuraman,
Sergiu Groppa,
Peter Brown

Affiliations

Damian M. Herz: MRC Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford
Manuel Bange: Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz
Gabriel Gonzalez-Escamilla: Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz
Miriam Auer: Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz
Keyoumars Ashkan: Department of Neurosurgery, King’s College Hospital
Petra Fischer: School of Physiology, Pharmacology and Neuroscience, University of Bristol
Huiling Tan: MRC Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford
Rafal Bogacz: MRC Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford
Muthuraman Muthuraman: Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz
Sergiu Groppa: Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz
Peter Brown: MRC Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford

DOI: https://doi.org/10.1038/s41467-022-35121-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The neural mechanisms determining the speed of decisions and movements in the human brain remain poorly understood. Here, the authors reveal that the subthalamic nucleus causally controls decision and movement speed independently for each hemisphere.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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