Regioselective synergic catalytic C-H activation: Unprecedented formation of sporadic 4-substituted (oxo-diaryl alkyl) isoquinolinium salts using SA-NEt2 catalyst

Abstract

First regioselective synergic CH bond activation at C-4 position of isoquinoline has been developed using isoquinoline, benzyl bromides and chalcones. An economic, efficient and one pot, synergically catalysed, aziridine intermediated synthesis of rare 4-substituted (oxo-diaryl alkyl) isoquinolinium salt has been performed using recyclable heterogeneous bifunctional catalyst Silica-Alumina supported 3-(diethylamino)propyl functional group (SA-NEt2) in good to moderate yield (82–71%).

Keywords

• Synergic
• C-H bond activation
• 4-substituted isoquinolinium salts
• SA-NEt2