Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
Kseniya Bushmeleva,
Alexandra Vyshtakalyuk,
Dmitriy Terenzhev,
Timur Belov,
Andrey Parfenov,
Natalia Sharonova,
Evgeniy Nikitin,
Vladimir Zobov
Affiliations
Kseniya Bushmeleva
Laboratory for Plant Raw Material Conversion for Organic Farming, Federal State Budgetary Institution of Science Federal Research Center, Kazan Scientific Center of Russian Academy of Sciences, 2/31 Lobachevskogo Str., 420111 Tatarstan, Russia
Alexandra Vyshtakalyuk
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, Russia
Dmitriy Terenzhev
Laboratory for Plant Raw Material Conversion for Organic Farming, Federal State Budgetary Institution of Science Federal Research Center, Kazan Scientific Center of Russian Academy of Sciences, 2/31 Lobachevskogo Str., 420111 Tatarstan, Russia
Timur Belov
Laboratory for Plant Raw Material Conversion for Organic Farming, Federal State Budgetary Institution of Science Federal Research Center, Kazan Scientific Center of Russian Academy of Sciences, 2/31 Lobachevskogo Str., 420111 Tatarstan, Russia
Andrey Parfenov
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, Russia
Natalia Sharonova
Laboratory for Plant Raw Material Conversion for Organic Farming, Federal State Budgetary Institution of Science Federal Research Center, Kazan Scientific Center of Russian Academy of Sciences, 2/31 Lobachevskogo Str., 420111 Tatarstan, Russia
Evgeniy Nikitin
Laboratory for Plant Raw Material Conversion for Organic Farming, Federal State Budgetary Institution of Science Federal Research Center, Kazan Scientific Center of Russian Academy of Sciences, 2/31 Lobachevskogo Str., 420111 Tatarstan, Russia
Vladimir Zobov
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, Russia
Researchers are attracted to the wide-ranging, useful components in Aronia melanocarpa berries. They are searching for the most effective ways to extract the active substances that can enhance the body’s protective properties. The current study presents detailed information about the extracts from A. melanocarpa fruits frozen and dried under mild conditions and their chemical composition. In Wistar rats with induced immunosuppression, the effect of chokeberry fruit extracts on the leukocyte formula, phagocytic activity, and cytokine system was studied. It was shown that the A. melanocarpa frozen fruit extract contains more anthocyanins, sugars, and ascorbic acid, and has a more pronounced antioxidant activity determined by the ability to bind APPH-radicals. Moreover, the extract showed membrane-protective and cytoprotective properties against RPMI-1788 cell line. The extract from dried raw material shows a higher antioxidant activity due to the ability to bind DPPH-radicals. It was revealed that extracts from A. melanocarpa fruits promote rapid immune system recovery in rats, normalize the leukocyte count, and improve monocyte and neutrophil phagocytic indicators. Research on the cytokine profile revealed that the anti-inflammatory properties in A. melanocarpa extracts were more pronounced in dried extracts. For several cytokines, a normalization of quantity was noted.
