Acta Cirúrgica Brasileira (May 2016)

Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats

  • Eros Luiz de Sousa,
  • Antônio Felipe Paulino de Figueiredo Wouk,
  • Osvaldo Malafaia,
  • Jurandir Marcondes Ribas-Filho,
  • Lucia Noronha,
  • Silvana Maris Cirio,
  • Claudia Turra PimpãoVII,
  • Carlos Hespanha Marinho Júnior,
  • Maria Fernanda Torres,
  • Yorgos Luiz Santos de Salles Graça,
  • Daniel Dantas Ferrarin

DOI
https://doi.org/10.1590/S0102-865020160050000005
Journal volume & issue
Vol. 31, no. 5
pp. 320 – 326

Abstract

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ABSTRACT PURPOSE : To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use. METHODS: Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9. RESULTS: Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods. CONCLUSION: The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.

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