Nature Communications (Nov 2016)
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
- Yelin Wu,
- Yanchun Quan,
- Yuanqi Liu,
- Keiwei Liu,
- Hongquan Li,
- Ziwei Jiang,
- Tian Zhang,
- Hu Lei,
- Katherine A. Radek,
- Dongqing Li,
- Zhenhua Wang,
- Jilong Lu,
- Wang Wang,
- Shizhao Ji,
- Zhaofan Xia,
- Yuping Lai
Affiliations
- Yelin Wu
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Yanchun Quan
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Yuanqi Liu
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Keiwei Liu
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Hongquan Li
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Ziwei Jiang
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Tian Zhang
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Hu Lei
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Katherine A. Radek
- Department of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago, Health Sciences Campus
- Dongqing Li
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Zhenhua Wang
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Jilong Lu
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Wang Wang
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Shizhao Ji
- Burn Institute of Chinese PLA and Department of Burn Surgery, Changhai Hospital, Second Military Medical University
- Zhaofan Xia
- Burn Institute of Chinese PLA and Department of Burn Surgery, Changhai Hospital, Second Military Medical University
- Yuping Lai
- Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- DOI
- https://doi.org/10.1038/ncomms13393
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.
