Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)

Abstract

In the historical aspect, experimental studies on rabbits conducted after the discovery of penicillin are described in order to develop single doses of the antibiotic and the frequency of its administration. The effectiveness of specific therapy of patients with syphilis with crystalline penicillin, Durant drugs in monotherapy, in combination with bismuth and non-specific therapy was evaluated. Electron microscopic studies that established the mechanism of action of penicillin on Treponema, the appearance of cysts and L-forms of the pathogen, the role of the macroorganism and stimulating therapy in the completion of phagocytosis are highlighted. It reflects the discussions of leading scientists at congresses that contribute to the development of effective treatment regimens for patients with syphilis.

Keywords

• syphilis
• penicillin
• treatment regimens
• experimental studies
• effectiveness of therapy