Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

Kaiyuan Ni; Guangxu Lan; Christina Chan; Bryan Quigley; Kuangda Lu; Theint Aung; Nining Guo; Patrick La Riviere; Ralph R. Weichselbaum; Wenbin Lin

doi:10.1038/s41467-018-04703-w

Nature Communications (Jun 2018)

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

Kaiyuan Ni,
Guangxu Lan,
Christina Chan,
Bryan Quigley,
Kuangda Lu,
Theint Aung,
Nining Guo,
Patrick La Riviere,
Ralph R. Weichselbaum,
Wenbin Lin

Affiliations

Kaiyuan Ni: Department of Chemistry, The University of Chicago
Guangxu Lan: Department of Chemistry, The University of Chicago
Christina Chan: Department of Chemistry, The University of Chicago
Bryan Quigley: Department of Radiology, The University of Chicago
Kuangda Lu: Department of Chemistry, The University of Chicago
Theint Aung: Department of Chemistry, The University of Chicago
Nining Guo: Department of Chemistry, The University of Chicago
Patrick La Riviere: Department of Radiology, The University of Chicago
Ralph R. Weichselbaum: Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research, The University of Chicago
Wenbin Lin: Department of Chemistry, The University of Chicago

DOI: https://doi.org/10.1038/s41467-018-04703-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Radiotherapy is known to have local immunomodulatory effects, while an effective systemic immune response is an issue. Here, the authors report on nMOF radiosensitizers for enhanced radiotherapy which in combination with anti-PD-L1 antibodies result in a systemic immune response to distant tumors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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