Nature Communications (Jul 2019)
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
- Sai P. Pydi,
- Shanu Jain,
- Wesley Tung,
- Yinghong Cui,
- Lu Zhu,
- Wataru Sakamoto,
- Shalini Jain,
- Brent S. Abel,
- Monica C. Skarulis,
- Jie Liu,
- Thanh Huynh,
- Karel Pacak,
- Marc G. Caron,
- Oksana Gavrilova,
- Toren Finkel,
- Jürgen Wess
Affiliations
- Sai P. Pydi
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Shanu Jain
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Wesley Tung
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Yinghong Cui
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Lu Zhu
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Wataru Sakamoto
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Shalini Jain
- Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases
- Brent S. Abel
- Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases
- Monica C. Skarulis
- Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases
- Jie Liu
- Center for Molecular Medicine, National Heart, Lung, and Blood Institute
- Thanh Huynh
- Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Karel Pacak
- Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Marc G. Caron
- Department of Cell Biology, Duke University Medical Center
- Oksana Gavrilova
- Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases
- Toren Finkel
- Center for Molecular Medicine, National Heart, Lung, and Blood Institute
- Jürgen Wess
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- DOI
- https://doi.org/10.1038/s41467-019-11003-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Beta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and metabolic complications.
