Journal of Circadian Rhythms (Apr 2024)
Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking
- Sangeeta Chawla,
- John O’Neill,
- Marina I. Knight,
- Yuqing He,
- Lei Wang,
- Erik Maronde,
- Sergio Gil Rodríguez,
- Gerben van Ooijen,
- Eduardo Garbarino-Pico,
- Eva Wolf,
- Ouria Dkhissi-Benyahya,
- Anjoom Nikhat,
- Shaon Chakrabarti,
- Shawn D. Youngstedt,
- Natalie Zi-Ching Mak,
- Ignacio Provencio,
- Henrik Oster,
- Namni Goel,
- Mario Caba,
- Maria Oosthuizen,
- Giles E. Duffield,
- Christopher Chabot,
- Seth J. Davis
Affiliations
- Sangeeta Chawla
- ORCiD
- Department of Biology, University of York, York YO105DD
- John O’Neill
- ORCiD
- MRC Laboratory of Molecular Biology Cambridge
- Marina I. Knight
- ORCiD
- Department of Mathematics, University of York, York YO105DD
- Yuqing He
- Key Laboratory of Plant Molecular Physiology, CAS Center for Excellence in Molecular Plant Sciences, China National Botanical Garden, Beijing 100093
- Lei Wang
- Key Laboratory of Plant Molecular Physiology, CAS Center for Excellence in Molecular Plant Sciences, China National Botanical Garden, Beijing 100093
- Erik Maronde
- ORCiD
- Institut für Anatomie II, Dr. Senckenbergische Anatomie, Goethe- Universität Frankfurt, Theodor-Stern-Kai-7, 60590 Frankfurt
- Sergio Gil Rodríguez
- School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh EH9 3BF
- Gerben van Ooijen
- ORCiD
- School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh EH9 3BF
- Eduardo Garbarino-Pico
- ORCiD
- Universidad Nacional de Córdoba (UNC), Facultad de Ciencias Químicas, Departamento de Química Biológica Ranwel Caputto, Córdoba; CONICET-UNC, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Córdoba
- Eva Wolf
- Institute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Hanns-Dieter-Hüsch- Weg 17, 55128 Mainz
- Ouria Dkhissi-Benyahya
- ORCiD
- Inserm, Stem Cell and Brain Research Institute U1208, Univ Lyon, Université Claude Bernard Lyon 1, 18 Avenue du Doyen Lépine, 69500, Bron
- Anjoom Nikhat
- Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Bangalore, Karnataka 560065
- Shaon Chakrabarti
- ORCiD
- Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Bangalore, Karnataka 560065
- Shawn D. Youngstedt
- Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ; Department of Medicine, University of Arizona, Tucson, AZ
- Natalie Zi-Ching Mak
- Department of Medicine, University of Arizona, Tucson, AZ
- Ignacio Provencio
- ORCiD
- Department of Biology and Department of Ophthalmology, University of Virginia, Charlottesville, VA
- Henrik Oster
- Institute of Neurobiology, Center for Brain, Behavior & Metabolism (CBBM), University of Luebeck, 23562 Luebeck
- Namni Goel
- ORCiD
- Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL
- Mario Caba
- ORCiD
- Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Ver.
- Maria Oosthuizen
- ORCiD
- Department of Zoology and Entomology, University of Pretoria, Pretoria; Mammal Research Institute, University of Pretoria, Hatfield
- Giles E. Duffield
- ORCiD
- Department of Biological Sciences, Galvin Life Science Center, University of Notre Dame, Notre Dame
- Christopher Chabot
- ORCiD
- Department of Biological Sciences, Plymouth State University, Plymouth, NH 03264
- Seth J. Davis
- ORCiD
- Department of Biology, University of York, York YO105DD, UK; State Key Laboratory of Crop Stress Biology, School of Life Sciences, Henan University, Kaifeng 475004
- DOI
- https://doi.org/10.5334/jcr.237
- Journal volume & issue
-
Vol. 22
pp. 2 – 2
Abstract
Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the physiological and ecological implications. Here we present some unresolved questions in circadian biology research as posed by the editorial staff and guest contributors to the Journal of Circadian Rhythms. This collection of ideas is not meant to be comprehensive but does reveal the breadth of our observations on emerging trends in chronobiology and circadian biology. It is amazing what could be achieved with various expected innovations in technologies, techniques, and mathematical tools that are being developed. We fully expect strengthening mechanistic work will be linked to health care and environmental understandings of circadian function. Now that most clock genes are known, linking these to physiological, metabolic, and developmental traits requires investigations from the single molecule to the terrestrial ecological scales. Real answers are expected for these questions over the next decade. Where are the circadian clocks at a cellular level? How are clocks coupled cellularly to generate organism level outcomes? How do communities of circadian organisms rhythmically interact with each other? In what way does the natural genetic variation in populations sculpt community behaviors? How will methods development for circadian research be used in disparate academic and commercial endeavors? These and other questions make it a very exciting time to be working as a chronobiologist.
Keywords
- circadian
- redox
- modeling
- photoperiod
- allelic variation
- phenotypes
- algae
- liquid-liquid phase separation
- structural biology
- retina
- melatonin
- synchrony
- entrainment
- immunity
- sleep
- food-entrainable oscillator
- chronotherapy
- circadian alignment
- urbanisation
- crop plants
- circatidal
- circalunar
- mosquito biting
- seasonal migration
- imaging