FEATURES OF PROPHYLAXIS OF POSTOPERATIVE VENOUS THROMBOEMBOLISM IN ONCOLOGIC PATIENTS

Abstract

Purpose: to study methods of prophylaxis of venous thromboembolism (VTE) in oncologic patients.Materials and methods: results of treatment of 92 patients with various options of an abdominal cancer were analysed. 43 patients (I group) received low-molecular-weight heparin (LMWH) as agent of anticoagulant prevention (enoxaparin 40 mg subcutaneuosly per day for 10 days). The 2nd group was presented by 49 patients, not received anticoagulant therapy. Coagulation profiles, D-dimers and liver function tests were studied.Results: in I group popliteal vein thrombosis was revealed in 2 (4,7%) cases. In two patients (4,7%) varicothromboflebitis was revealed. In 2nd group femoropopliteal thrombosis was diagnosed in 5 patients (10,2%) and thrombosis of superficial veins of lower extremities in 3 patients (6,1%).Summary: it is more preferable to use LMWH for prevention of VTE. An adequate laboratory control in such patients and selection of an individual dose depends on results of APTT (activated partial thromboplastin time). Especially it concerns to patients with metastatic liver cancer and another groups of high-risk cancer patients.

Keywords

• oncologic patients
• venous thromboembolism
• anticoagulant therapy