Sarcoma (Jan 2012)
Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma
- Sergey Malchenko,
- Elisabeth A. Seftor,
- Yuri Nikolsky,
- Susan L. Hasegawa,
- Sean Kuo,
- Jeff W. Stevens,
- Stas Poyarkov,
- Tatiana Nikolskaya,
- Tamara Kucaba,
- Min Wang,
- Hakim Abdulkawy,
- Thomas Casavant,
- Jose Morcuende,
- Joseph Buckwalter,
- Raymond Hohl,
- Barry DeYoung,
- Kemp Kernstine,
- Maria de Fatima Bonaldo,
- Mary J. C. Hendrix,
- Marcelo B. Soares,
- Vera Maria F. C. Soares
Affiliations
- Sergey Malchenko
- Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
- Elisabeth A. Seftor
- Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
- Yuri Nikolsky
- GeneGo, Inc., 500 Renaissance Drive, No. 106, St. Joseph, MI 49085, USA
- Susan L. Hasegawa
- Department of Pathology and Laboratory Medicine, Children’s Memorial Hospital 2300 Children’s Plaza, Chicago, IL 60614, USA
- Sean Kuo
- Center for Bioinformatics and Computation Biology, University of Iowa, 5316 Seamans Center, Iowa City, IA 52242, USA
- Jeff W. Stevens
- Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Stas Poyarkov
- Vavilov Institute for General Genetics, Russian Academy of Sciences, 3 Gubkina Street, Moscow 117093, Russia
- Tatiana Nikolskaya
- Vavilov Institute for General Genetics, Russian Academy of Sciences, 3 Gubkina Street, Moscow 117093, Russia
- Tamara Kucaba
- Department of Urology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Min Wang
- Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
- Hakim Abdulkawy
- Center for Bioinformatics and Computation Biology, University of Iowa, 5316 Seamans Center, Iowa City, IA 52242, USA
- Thomas Casavant
- Center for Bioinformatics and Computation Biology, University of Iowa, 5316 Seamans Center, Iowa City, IA 52242, USA
- Jose Morcuende
- Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Joseph Buckwalter
- Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Raymond Hohl
- Department of Hematology/Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Barry DeYoung
- Department of Surgical Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Kemp Kernstine
- Lung Cancer and Thoracic Oncology Program, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
- Maria de Fatima Bonaldo
- Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
- Mary J. C. Hendrix
- Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
- Marcelo B. Soares
- Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
- Vera Maria F. C. Soares
- Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
- DOI
- https://doi.org/10.1155/2012/820254
- Journal volume & issue
-
Vol. 2012
Abstract
Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.
