Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis
Roberto Cannataro,
Maria Cristina Caroleo,
Alessia Fazio,
Chiara La Torre,
Pierluigi Plastina,
Luca Gallelli,
Graziantonio Lauria,
Erika Cione
Affiliations
Roberto Cannataro
GalaScreen Laboratories, Mater Domini Hospital 88100 Catanzaro and Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende (CS), Italy
Maria Cristina Caroleo
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy
Alessia Fazio
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy
Chiara La Torre
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy
Pierluigi Plastina
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy
Luca Gallelli
Clinical Pharmacology and Pharmacovigilance Operative Unit, Department of Health Science, University of Magna Graecia, Mater Domini Hospital Catanzaro, 88100 Catanzaro, Italy
Graziantonio Lauria
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy
Erika Cione
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy
Recently, we demonstrated the capability of the ketogenic diet (KD) to influence the microRNA (miR) expression profile. Here, we report that KD is able to normalize miR expression in obese subjects when compared with lean subjects. By applying two different bioinformatics tools, we found that, amongst the miRs returning to comparable levels in lean subjects, four of them are linked to antioxidant biochemical pathways specifically, and the others are linked to both antioxidant and anti-inflammatory biochemical pathways. Of particular interest is the upregulation of hsa-miR-30a-5p, which correlates with the decrease of catalase expression protein in red blood cells.
