Nature Communications (Aug 2022)
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
- Yu Yuan,
- Dawid Jaślan,
- Taufiq Rahman,
- Stephen R. Bolsover,
- Vikas Arige,
- Larry E. Wagner,
- Carla Abrahamian,
- Rachel Tang,
- Marco Keller,
- Jonas Hartmann,
- Anna S. Rosato,
- Eva-Maria Weiden,
- Franz Bracher,
- David I. Yule,
- Christian Grimm,
- Sandip Patel
Affiliations
- Yu Yuan
- Department of Cell and Developmental Biology, University College London
- Dawid Jaślan
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University
- Taufiq Rahman
- Department of Pharmacology, University of Cambridge
- Stephen R. Bolsover
- Department of Cell and Developmental Biology, University College London
- Vikas Arige
- Department of Pharmacology and Physiology, University of Rochester
- Larry E. Wagner
- Department of Pharmacology and Physiology, University of Rochester
- Carla Abrahamian
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University
- Rachel Tang
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University
- Marco Keller
- Department of Pharmacy—Center for Drug Research, Ludwig-Maximilians University
- Jonas Hartmann
- Department of Cell and Developmental Biology, University College London
- Anna S. Rosato
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University
- Eva-Maria Weiden
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University
- Franz Bracher
- Department of Pharmacy—Center for Drug Research, Ludwig-Maximilians University
- David I. Yule
- Department of Pharmacology and Physiology, University of Rochester
- Christian Grimm
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University
- Sandip Patel
- Department of Cell and Developmental Biology, University College London
- DOI
- https://doi.org/10.1038/s41467-022-31959-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
TPC2 is a lysosomal ion channel permeable to both calcium and sodium ions. Here, the authors show that TPC2 can selectively increase its calcium permeability when simultaneously challenged by both its natural activators- NAADP and PI(3,5)P2.
