Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

Abstract

Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase spindle migration, resulting in cortical protrusion.