Nature Communications (Oct 2016)
Loss of immune tolerance to IL-2 in type 1 diabetes
- Louis Pérol,
- John M. Lindner,
- Pamela Caudana,
- Nicolas Gonzalo Nunez,
- Audrey Baeyens,
- Andrea Valle,
- Christine Sedlik,
- Delphine Loirat,
- Olivier Boyer,
- Alain Créange,
- José Laurent Cohen,
- Ute Christine Rogner,
- Jun Yamanouchi,
- Martine Marchant,
- Xavier Charles Leber,
- Meike Scharenberg,
- Marie-Claude Gagnerault,
- Roberto Mallone,
- Manuela Battaglia,
- Pere Santamaria,
- Agnès Hartemann,
- Elisabetta Traggiai,
- Eliane Piaggio
Affiliations
- Louis Pérol
- Sorbonne Universités, Pierre and Marie Curie University Paris 06
- John M. Lindner
- Novartis Institutes for Biomedical Research
- Pamela Caudana
- Institut Curie, PSL Research University, INSERM U932
- Nicolas Gonzalo Nunez
- Institut Curie, PSL Research University, INSERM U932
- Audrey Baeyens
- Sorbonne Universités, Pierre and Marie Curie University Paris 06
- Andrea Valle
- Diabetes Research Institute (DRI), IRCCS San Raffaele Scientific Institute
- Christine Sedlik
- Institut Curie, PSL Research University, INSERM U932
- Delphine Loirat
- Translational Research Department, SiRIC TransImm Translational Immunotherapy Team, Research Center, PSL Research University, Institut Curie
- Olivier Boyer
- INSERM, U905
- Alain Créange
- Service de Neurologie, Groupe Hospitalier Henri Mondor, AP-HP
- José Laurent Cohen
- Université Paris-Est Créteil
- Ute Christine Rogner
- Département Biologie du développement et cellules souches, Institut Pasteur, CNRS URA 2578
- Jun Yamanouchi
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine. University of Calgary
- Martine Marchant
- Novartis Institutes for Biomedical Research
- Xavier Charles Leber
- Novartis Institutes for Biomedical Research
- Meike Scharenberg
- Novartis Institutes for Biomedical Research
- Marie-Claude Gagnerault
- INSERM, U1016, Cochin Institute, DeAR Lab
- Roberto Mallone
- INSERM, U1016, Cochin Institute, DeAR Lab
- Manuela Battaglia
- Diabetes Research Institute (DRI), IRCCS San Raffaele Scientific Institute
- Pere Santamaria
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine. University of Calgary
- Agnès Hartemann
- Department of Medicine Faculty, Université Pierre et Marie Curie—Paris 6
- Elisabetta Traggiai
- Novartis Institutes for Biomedical Research
- Eliane Piaggio
- Sorbonne Universités, Pierre and Marie Curie University Paris 06
- DOI
- https://doi.org/10.1038/ncomms13027
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.
