Communications Medicine (Dec 2021)

Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia

  • Katherine Phan,
  • Ying He,
  • YuHong Fu,
  • Nicolas Dzamko,
  • Surabhi Bhatia,
  • Julian Gold,
  • Dominic Rowe,
  • Yazi D. Ke,
  • Lars M. Ittner,
  • John R. Hodges,
  • Olivier Piguet,
  • Matthew C. Kiernan,
  • Glenda M. Halliday,
  • Woojin Scott Kim

DOI
https://doi.org/10.1038/s43856-021-00060-w
Journal volume & issue
Vol. 1, no. 1
pp. 1 – 11

Abstract

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Phan et al. assess the presence of human endogenous retrovirus K (HERV-K) in the serum and brain samples of individuals with behavioral variant frontotemporal dementia (bvFTD) with TDP-43 pathology, as seen in amyotrophic lateral sclerosis. The authors show HERV-K is associated with manifestations of bvFTD with TDP-43 pathology.