A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

Yiqun Zhang; Fengju Chen; Lawrence A. Donehower; Michael E. Scheurer; Chad J. Creighton

doi:10.1038/s41467-021-21081-y

Nature Communications (Feb 2021)

A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

Yiqun Zhang,
Fengju Chen,
Lawrence A. Donehower,
Michael E. Scheurer,
Chad J. Creighton

Affiliations

Yiqun Zhang: Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine
Fengju Chen: Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine
Lawrence A. Donehower: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Michael E. Scheurer: Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine
Chad J. Creighton: Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-021-21081-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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The global impact of somatic structural variants (SSVs) on gene expression in childhood cancers is unclear. Here, the authors analyse cancer genome and RNA sequencing data of 854 pediatric brain tumours and report a landscape of genes deregulated by SSVs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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