International Journal of Nanomedicine (Aug 2020)

Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery

  • Hua Y,
  • Chen L,
  • Hou C,
  • Liu S,
  • Pei Z,
  • Lu Y

Journal volume & issue
Vol. Volume 15
pp. 5873 – 5899

Abstract

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Yijie Hua,1,* Lan Chen,1,* Chenxi Hou,2 Shengbo Liu,3 Zhichao Pei,2 Yuchao Lu1 1Analysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of China; 2College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China; 3School of Chemistry, Biology, and Material Engineering, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchao LuAnalysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of ChinaTel/ Fax +86 317 560 5226Email [email protected] PeiCollege of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of ChinaTel +86 298 709 1196Fax +86 298 709 2769Email [email protected]: Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pillar[n]arenes. Second, we examine supramolecular vesicles composed of amphiphilic pillar[n]arenes recently used for the construction of SDDs. In addition, we describe the prospects for multifunctional amphiphilic pillar[n]arenes, particularly their potential in novel applications.Keywords: supramolecular vesicles, amphiphilic pillar[n]arenes, smart, drug delivery

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