Nature Communications (Dec 2019)
Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor
- Andrew J. Murphy,
- Xiang Chen,
- Emilia M. Pinto,
- Justin S. Williams,
- Michael R. Clay,
- Stanley B. Pounds,
- Xueyuan Cao,
- Lei Shi,
- Tong Lin,
- Geoffrey Neale,
- Christopher L. Morton,
- Mary A. Woolard,
- Heather L. Mulder,
- Hyea Jin Gil,
- Jerold E. Rehg,
- Catherine A. Billups,
- Matthew L. Harlow,
- Jeffrey S. Dome,
- Peter J. Houghton,
- John Easton,
- Jinghui Zhang,
- Rani E. George,
- Gerard P. Zambetti,
- Andrew M. Davidoff
Affiliations
- Andrew J. Murphy
- Department of Surgery, St. Jude Children’s Research Hospital
- Xiang Chen
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Emilia M. Pinto
- Department of Pathology, St. Jude Children’s Research Hospital
- Justin S. Williams
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Michael R. Clay
- Department of Pathology, St. Jude Children’s Research Hospital
- Stanley B. Pounds
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Xueyuan Cao
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Lei Shi
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Tong Lin
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Geoffrey Neale
- Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital
- Christopher L. Morton
- Department of Surgery, St. Jude Children’s Research Hospital
- Mary A. Woolard
- Department of Surgery, St. Jude Children’s Research Hospital
- Heather L. Mulder
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Hyea Jin Gil
- Department of Surgery, St. Jude Children’s Research Hospital
- Jerold E. Rehg
- Department of Pathology, St. Jude Children’s Research Hospital
- Catherine A. Billups
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Matthew L. Harlow
- Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children’s Hospital, Harvard Medical School
- Jeffrey S. Dome
- Division of Oncology, Children’s National Medical Center
- Peter J. Houghton
- Greehey Children’s Cancer Research Institute, University of Texas Health Science Center
- John Easton
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jinghui Zhang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Rani E. George
- Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children’s Hospital, Harvard Medical School
- Gerard P. Zambetti
- Department of Pathology, St. Jude Children’s Research Hospital
- Andrew M. Davidoff
- Department of Surgery, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-019-13646-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The progress in pre-clinical drug discovery for Wilms tumor (WT) is limited by a lack of disease models. Here, the authors develop 45 heterotopic WT patient-derived xenografts including several anaplastic models that recapitulate the biological heterogeneity of WT, and propose this as a resource for evaluating future therapeutics for WT.
