Scientific Reports (Jul 2021)

Maternal outcomes and risk factors for COVID-19 severity among pregnant women

  • Manon Vouga,
  • Guillaume Favre,
  • Oscar Martinez-Perez,
  • Leo Pomar,
  • Laura Forcen Acebal,
  • Alejandra Abascal-Saiz,
  • Maria Rosa Vila Hernandez,
  • Najeh Hcini,
  • Véronique Lambert,
  • Gabriel Carles,
  • Joanna Sichitiu,
  • Laurent Salomon,
  • Julien Stirnemann,
  • Yves Ville,
  • Begoña Martinez de Tejada,
  • Anna Goncé,
  • Ameth Hawkins-Villarreal,
  • Karen Castillo,
  • Eduard Gratacos Solsona,
  • Lucas Trigo,
  • Brian Cleary,
  • Michael Geary,
  • Helena Bartels,
  • Feras Al-Kharouf,
  • Fergal Malone,
  • Mary Higgins,
  • Niamh Keating,
  • Susan Knowles,
  • Christophe Poncelet,
  • Carolina Carvalho Ribeiro-do-Valle,
  • Fernanda Surita,
  • Amanda Dantas-Silva,
  • Carolina Borrelli,
  • Adriana Gomes Luz,
  • Javiera Fuenzalida,
  • Jorge Carvajal,
  • Manuel Guerra Canales,
  • Olivia Hernandez,
  • Olga Grechukhina,
  • Albert I. Ko,
  • Uma Reddy,
  • Rita Figueiredo,
  • Marina Moucho,
  • Pedro Viana Pinto,
  • Carmen De Luca,
  • Marco De Santis,
  • Diogo Ayres de Campos,
  • Inês Martins,
  • Charles Garabedian,
  • Damien Subtil,
  • Betania Bohrer,
  • Maria Lucia Da Rocha Oppermann,
  • Maria Celeste Osorio Wender,
  • Lavinia Schuler-Faccini,
  • Maria Teresa Vieira Sanseverino,
  • Camila Giugliani,
  • Luciana Friedrich,
  • Mariana Horn Scherer,
  • Nicolas Mottet,
  • Guillaume Ducarme,
  • Helene Pelerin,
  • Chloe Moreau,
  • Bénédicte Breton,
  • Thibaud Quibel,
  • Patrick Rozenberg,
  • Eric Giannoni,
  • Cristina Granado,
  • Cécile Monod,
  • Doris Mueller,
  • Irene Hoesli,
  • Dirk Bassler,
  • Sandra Heldstab,
  • Nicole Ochsenbein Kölble,
  • Loïc Sentilhes,
  • Melissa Charvet,
  • Jan Deprest,
  • Jute Richter,
  • Lennart Van der Veeken,
  • Béatrice Eggel-Hort,
  • Gaetan Plantefeve,
  • Mohamed Derouich,
  • Albaro José Nieto Calvache,
  • Maria Camila Lopez-Giron,
  • Juan Manuel Burgos-Luna,
  • Maria Fernanda Escobar-Vidarte,
  • Kurt Hecher,
  • Ann-Christin Tallarek,
  • Eran Hadar,
  • Karina Krajden Haratz,
  • Uri Amikam,
  • Gustavo Malinger,
  • Ron Maymon,
  • Yariv Yogev,
  • Leonhard Schäffer,
  • Arnaud Toussaint,
  • Marie-Claude Rossier,
  • Renato Augusto Moreira De Sa,
  • Claudia Grawe,
  • Karoline Aebi-Popp,
  • Anda-Petronela Radan,
  • Luigi Raio,
  • Daniel Surbek,
  • Paul Böckenhoff,
  • Brigitte Strizek,
  • Martin Kaufmann,
  • Andrea Bloch,
  • Michel Boulvain,
  • Silke Johann,
  • Sandra Andrea Heldstab,
  • Monya Todesco Bernasconi,
  • Gaston Grant,
  • Anis Feki,
  • Anne-Claude Muller Brochut,
  • Marylene Giral,
  • Lucie Sedille,
  • Andrea Papadia,
  • Romina Capoccia Brugger,
  • Brigitte Weber,
  • Tina Fischer,
  • Christian Kahlert,
  • Karin Nielsen Saines,
  • Mary Cambou,
  • Panagiotis Kanellos,
  • Xiang Chen,
  • Mingzhu Yin,
  • Annina Haessig,
  • Sandrine Ackermann,
  • David Baud,
  • Alice Panchaud

DOI
https://doi.org/10.1038/s41598-021-92357-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Abstract Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.