Research progress of acidic nucleoplasmic DNA-binding protein 1

Abstract

Acidic nucleoplasmic DNA-binding protein 1 (And-1/WDHD1) as a natural chimerical protein, is characterized by containing the WD-repeat and the HMG-box motif families. And-1 is over-expressed in multiple tumors and involved in the whole cell cycle containing prereplication complex (Pre-RC) assembly, DNA replication, checkpoint activation, DNA repair and sister chromatid cohesion establishment. As a novel target for cell cycle regulation, And-1 can be used in the development of broad-spectrum anti-cancer drugs. This article focuses on the research on the structural characteristics, biochemical functions and potential roles of And-1 in cancer in recent years, in order to provide references for the further research of And-1 and the development of new drugs.

Keywords

• acidic nucleoplasmic dna-binding protein 1(and-1)|wd40(wd-repeat)|high mobility group(hmg)|novel target