Frontiers in Neuroscience (Mar 2019)
Ipsilesional Mu Rhythm Desynchronization and Changes in Motor Behavior Following Post Stroke BCI Intervention for Motor Rehabilitation
- Alexander B. Remsik,
- Alexander B. Remsik,
- Alexander B. Remsik,
- Leroy Williams,
- Leroy Williams,
- Leroy Williams,
- Klevest Gjini,
- Klevest Gjini,
- Keith Dodd,
- Keith Dodd,
- Jaclyn Thoma,
- Jaclyn Thoma,
- Tyler Jacobson,
- Tyler Jacobson,
- Matt Walczak,
- Matthew McMillan,
- Matthew McMillan,
- Shruti Rajan,
- Shruti Rajan,
- Brittany M. Young,
- Brittany M. Young,
- Brittany M. Young,
- Brittany M. Young,
- Brittany M. Young,
- Zack Nigogosyan,
- Hemali Advani,
- Rosaleena Mohanty,
- Rosaleena Mohanty,
- Neelima Tellapragada,
- Janerra Allen,
- Mohsen Mazrooyisebdani,
- Leo M. Walton,
- Leo M. Walton,
- Peter L. E. van Kan,
- Theresa J. Kang,
- Theresa J. Kang,
- Justin A. Sattin,
- Veena A. Nair,
- Dorothy Farrar Edwards,
- Justin C. Williams,
- Justin C. Williams,
- Vivek Prabhakaran,
- Vivek Prabhakaran,
- Vivek Prabhakaran,
- Vivek Prabhakaran,
- Vivek Prabhakaran,
- Vivek Prabhakaran
Affiliations
- Alexander B. Remsik
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Alexander B. Remsik
- Department of Kinesiology, University of Wisconsin–Madison, Madison, WI, United States
- Alexander B. Remsik
- Institute for Clinical and Translational Research, University of Wisconsin–Madison, Madison, WI, United States
- Leroy Williams
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Leroy Williams
- Department of Educational Psychology, University of Wisconsin–Madison, Madison, WI, United States
- Leroy Williams
- Center for Women’s Health Research, University of Wisconsin–Madison, Madison, WI, United States
- Klevest Gjini
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Klevest Gjini
- Department of Neurology, University of Wisconsin–Madison, Madison, WI, United States
- Keith Dodd
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Keith Dodd
- Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI, United States
- Jaclyn Thoma
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Jaclyn Thoma
- Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Tyler Jacobson
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Tyler Jacobson
- Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Matt Walczak
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Matthew McMillan
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Matthew McMillan
- Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI, United States
- Shruti Rajan
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Shruti Rajan
- Department of Psychology, University of Wisconsin–Madison, Madison, WI, United States
- Brittany M. Young
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Brittany M. Young
- Institute for Clinical and Translational Research, University of Wisconsin–Madison, Madison, WI, United States
- Brittany M. Young
- Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Brittany M. Young
- 0Clinical Neuroengineering Training Program, University of Wisconsin–Madison, Madison, WI, United States
- Brittany M. Young
- 1Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Zack Nigogosyan
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Hemali Advani
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Rosaleena Mohanty
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Rosaleena Mohanty
- 2Department of Electrical and Computer Engineering, University of Wisconsin–Madison, Madison, WI, United States
- Neelima Tellapragada
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Janerra Allen
- 3Department of Materials Science and Engineering, University of Wisconsin–Madison, Madison, WI, United States
- Mohsen Mazrooyisebdani
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Leo M. Walton
- Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI, United States
- Leo M. Walton
- Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Peter L. E. van Kan
- Department of Kinesiology, University of Wisconsin–Madison, Madison, WI, United States
- Theresa J. Kang
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Theresa J. Kang
- Department of Neurology, University of Wisconsin–Madison, Madison, WI, United States
- Justin A. Sattin
- Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Veena A. Nair
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Dorothy Farrar Edwards
- Department of Kinesiology, University of Wisconsin–Madison, Madison, WI, United States
- Justin C. Williams
- Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI, United States
- Justin C. Williams
- 4Department of Neurological Surgery, University of Wisconsin–Madison, Madison, WI, United States
- Vivek Prabhakaran
- Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States
- Vivek Prabhakaran
- Department of Neurology, University of Wisconsin–Madison, Madison, WI, United States
- Vivek Prabhakaran
- Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Vivek Prabhakaran
- Department of Psychology, University of Wisconsin–Madison, Madison, WI, United States
- Vivek Prabhakaran
- 1Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
- Vivek Prabhakaran
- 5Department of Psychiatry, University of Wisconsin–Madison, Madison, WI, United States
- DOI
- https://doi.org/10.3389/fnins.2019.00053
- Journal volume & issue
-
Vol. 13
Abstract
Loss of motor function is a common deficit following stroke insult and often manifests as persistent upper extremity (UE) disability which can affect a survivor’s ability to participate in activities of daily living. Recent research suggests the use of brain–computer interface (BCI) devices might improve UE function in stroke survivors at various times since stroke. This randomized crossover-controlled trial examines whether intervention with this BCI device design attenuates the effects of hemiparesis, encourages reorganization of motor related brain signals (EEG measured sensorimotor rhythm desynchronization), and improves movement, as measured by the Action Research Arm Test (ARAT). A sample of 21 stroke survivors, presenting with varied times since stroke and levels of UE impairment, received a maximum of 18–30 h of intervention with a novel electroencephalogram-based BCI-driven functional electrical stimulator (EEG-BCI-FES) device. Driven by spectral power recordings from contralateral EEG electrodes during cued attempted grasping of the hand, the user’s input to the EEG-BCI-FES device modulates horizontal movement of a virtual cursor and also facilitates concurrent stimulation of the impaired UE. Outcome measures of function and capacity were assessed at baseline, mid-therapy, and at completion of therapy while EEG was recorded only during intervention sessions. A significant increase in r-squared values [reflecting Mu rhythm (8–12 Hz) desynchronization as the result of attempted movements of the impaired hand] presented post-therapy compared to baseline. These findings suggest that intervention corresponds with greater desynchronization of Mu rhythm in the ipsilesional hemisphere during attempted movements of the impaired hand and this change is related to changes in behavior as a result of the intervention. BCI intervention may be an effective way of addressing the recovery of a stroke impaired UE and studying neuromechanical coupling with motor outputs.Clinical Trial Registration:ClinicalTrials.gov, identifier NCT02098265.
Keywords
- brain–computer interface;
- hemiparesis; r-squared; coherence; chronic; acute; neuroplasticity; homunculus