Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy

Takefumi Hitomi; Morito Inouchi; Hirofumi Takeyama; Katsuya Kobayashi; Shamima Sultana; Takeshi Inoue; Yuko Nakayama; Akihiro Shimotake; Masao Matsuhashi; Riki Matsumoto; Kazuo Chin; Ryosuke Takahashi; Akio Ikeda

Epilepsy and Behavior Case Reports (Jan 2019)

Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy

Takefumi Hitomi,
Morito Inouchi,
Hirofumi Takeyama,
Katsuya Kobayashi,
Shamima Sultana,
Takeshi Inoue,
Yuko Nakayama,
Akihiro Shimotake,
Masao Matsuhashi,
Riki Matsumoto,
Kazuo Chin,
Ryosuke Takahashi,
Akio Ikeda

Affiliations

Takefumi Hitomi: Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan; Corresponding author at: Department of Neurology, Kyoto University Graduate School of Medicine, Department of Clinical Laboratory Medicine, Kyoto University School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.
Morito Inouchi: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Hirofumi Takeyama: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Katsuya Kobayashi: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Shamima Sultana: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Takeshi Inoue: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Yuko Nakayama: Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan
Akihiro Shimotake: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Masao Matsuhashi: Human Brain Research Center, Kyoto University Graduate School of Medicine, Japan
Riki Matsumoto: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Kazuo Chin: Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Ryosuke Takahashi: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Akio Ikeda: Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Journal volume & issue: Vol. 11
pp. 18 – 21

Abstract

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To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomnography (PSG) of 1 patient. Epileptiform discharges were significantly more frequent during the awake period (1.3 ± 1.2/min) than those during light sleep stages (0.02 ± 0.04/min) (P < 0.05). Regarding PSG analysis, epileptiform discharges were also reduced during all sleep stages compared to those during awake periods. Our study suggests a relative reduction in cortical irritability during sleep in BAFME. Keywords: Benign adult familial myoclonus epilepsy (BAFME), Epileptiform discharges, Effects of sleep modification on cortical irritability

Published in Epilepsy and Behavior Case Reports

ISSN: 2213-3232 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.journals.elsevier.com/epilepsy-and-behavior-case-reports/

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